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Defending champion Novak Djokovic followed Carlos Alcaraz out of the US Open in another seismic shock in New York as the 24-time Grand Slam champion was beaten by Australian 28th seed Alexei Popyrin on Friday night.
Less than 24 hours after third seed and 2022 champion Alcaraz crashed out of the tournament to Dutchman Botic van de Zandschulp, Djokovic was dethroned by 25-year-old Popyrin 6-4 6-4 2-6 6-4.
Chasing a record-extending 25th major title, Djokovic was playing his first tournament since winning the gold medal at the Paris Olympics.
But the Australian, who secured his maiden ATP Masters 1000 title in Montreal earlier this month, outmuscled 37-year-old Djokovic with a fearless brand of tennis to seal the biggest win of his career under the lights of Arthur Ashe Stadium.