Should Ireland lose against Scotland without gaining a bonus point, England will win the championship if they beat France and score four tries.
France, though, were back close to their best in a record win against Wales last weekend.
England, meanwhile, have not scored four tries in France since 1992.
The fact that England harbour any hopes of winning this Six Nations is tantamount to their impressive performance in derailing Ireland’s Grand Slam bid at Twickenham.
A similar performance will be required if England are to capitalise should Ireland fall short.
Victory would also avenge France’s 53-10 win at Twickenham last season, which was both England’s record home defeat in any Test, and a French record in this fixture.
“Not many teams come to France and win,” said captain Jamie George. “We haven’t done that since 2016. We’re very aware of that.
“We achieved something special last weekend, everyone felt that but being able to back it up is a huge motivation for me. Good teams react well to setbacks, great teams make sure they back it up.”
The hosts retain a mathematical chance of winning the title, although they could also finish as low as fifth should results go against them.
Even with a trophy almost out of reach the stakes remain high.
Beat England and France will have won four straight championship home games in this fixture for the first time since 1972; lose and they will have failed to win at home in a single campaign for the first time in the Six Nations era.