The Dragons duo will pack down against South Africa’s lock pairing of Eben Etzebeth and Franco Mostert, whose last international game together was the World Cup final victory against New Zealand in Paris in October 2023.
Etzebeth has more caps (119) than the Wales starting pack (118) and the Springboks starting pair on the weekend have 192 internationals between them.
In contrast, the Wales pair have 12 caps, which only includes five starts, but Carter insists they will not be overawed.
“They are the world champions so who better to test yourself against?
“I love playing with Screech, he has been a great help to me coming through at the Dragons and I’m looking forward to doing it in the Welsh shirt.”
Carter, 23, is the more experienced player on the international stage after starting five matches in his 11 Tests so far.
His last Test was against South Africa in the World Cup warm-up match when the Springboks beat Wales 52-16 in Cardiff in August.
Carter says he has a “bit of a point” to prove after the “devastation” of missing out on the global tournament in France.
He was then forced to sit out the Six Nations because of a hamstring injury.
Carter used that period to bulk up and hopes that will help him against the Springboks.
“I am probably five or six kilos bigger,” said Carter.
“I put a lot on when I was injured with my hamstring and in the first few games I was a bit worried it was too much, but I feel I have got used to it.
“If I can get to a point with my fitness levels where I was before, that will only be beneficial.
“One of my work-ons since the start of my professional career has been the collisions and physicality.
“This season I put a big focus on getting bigger and stronger to help in that aspect, so Saturday will be a brilliant test.”